This race brings a new twist to the series: an All-Stars cast consisting of past winners and high performers from previous Amazing Race seasons. Among those suspected to appear when the Race airs in January 2007 are:
- Bill and Joe (Team Guido) from the Amazing Race 1
- Kevin and Drew (Fraternity Brothers) from the Amazing Race 1
- Oswald and Danny (Team Cha Cha Cha) from the Amazing Race 2
- Teri and Ian (Married Parents) from the Amazing Race 3
- John Vito and Jill (Dating) from the Amazing Race 3
- Tian and Jaree (Friends/Models) from the Amazing Race 4
- Charla and Mirna (Cousins) from the Amazing Race 5
- Kris and Jon (Dating Long Distance) from the Amazing Race 6
- Rob and Amber (Engaged Couple) from the Amazing Race 7
- Joyce and Uchenna (Married Couple) from the Amazing Race 7
- Eric and Danielle were both on the Amazing Race 9, but not on the same team. Eric was one of The Frat Boys and Danielle was Childhood Friends with Dani
- Dustin and Kandice (Beauty Queens) from the Amazing Race 10
- David and Mary (Coalminer and Wife) from the Amazing Race 10


